NOD.CB17-PrkdcscidIl2rgtm1BcgenIl6tm1(IL6)Bcgen/Bcgen • 112864
| Product name | huHSC-B-NDG hIL6 mice |
|---|---|
| Catalog number | 112864 |
| Strain name | NOD.CB17-PrkdcscidIl2rgtm1BcgenIl6tm1(IL6)Bcgen/Bcgen |
| Strain background | B-NDG |
| NCBI gene ID | 16193,16186,19090 (Human) |
| Aliases | Il-6; gc; p64; [g]c; CD132; gamma(c); p460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; DNA-PKcs |
| Application | Promote differentiation of human monocyte-macrophage |
B-NDG hIL6 mice are well suited for human monocytes reconstitution. Human CD34+ HSCs (0.15 M) were intravenously implanted into homozygous B-NDG hIL6 and B-NDG mice (female, 6-week-old, n=15). All mice were treated with 1.6 Gy-irradiation. Flow cytometry analysis were performed with PBMCs from mice engrafted with human CD34+ HSCs. B-NDG hIL6 mice showed higher percentages of human myeloid cells and monocytes compared with B-NDG mice.
