C57BL/6N-Flt3lgtm1(FLT3LG)Bcgen/Bcgen • 112350
| Product name | B-hFLT3LG mice |
|---|---|
| Catalog number | 112350 |
| Strain name | C57BL/6N-Flt3lgtm1(FLT3LG)Bcgen/Bcgen |
| Strain background | C57BL/6N |
| NCBI gene ID | 2323 (Human) |
| Aliases | FL; FLG3L; FLT3L; IMD125 |
Gene targeting strategy for B-hFLT3LG mice. The exons 2~7 of mouse Flt3lg gene that encode the extracellular domain and the transmembrane domain were replaced by human FLT3LG exons 2~7 in B-hFLT3LG mice.
Strain specific FLT3LG expression analysis in homozygous B-hFLT3LG mice by ELISA. Serum were isolated from wild-type C57BL/6 mice (+/+) and homozygous B-hFLT3LG mice (H/H). Mouse FLT3LG was detectable in wild-type mice (A). Human FLT3LG was exclusively detectable in homozygous B-hFLT3LG mice (B).
